TY - JOUR ID - 40159 TI - Quantification of Proteinuria with Urinary Protein to Osmolality Ratios in Children JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Hooman, N. AU - Otoukesh, H. AU - Safaii, H. AU - Mehrazma, M. AU - Yousefi, S. AD - Departments of pediatric nephrology Iran University of medical sciences, Tehran, Iran AD - Departments of Pathology, Ali Asgar children hospital, Iran University of medical sciences, Tehran, Iran Y1 - 2015 PY - 2015 VL - 29 IS - 4 SP - 168 EP - 171 DO - N2 - Background: The ratio of urine protein to urine osmolality has recently been suggested as an accurate method to determine proteinuria.  Objective: We studied the correlation of urine protein to urine osmolality ratio with 24-hr urinary protein excretion. Methods: 150 children aged 0.11–17 years admitted to the Department of Pediatric Nephrology were included in this study. Early morning urine samples and 24-hr urine specimens were collected and analyzed for protein, creatinine, and osmolality. The patients with chronic renal failure were not excluded. Two groups were established: Children with no proteinuria (group 1) and those with proteinuria (group 2).  Results: The optimal cutoff value of abnormal proteinuria and nephrotic range proteinuria was determined to be a protein–osmolality ratio (Up/Uosm) 0.27 and 1.59 mg/l/mOsm respectively. The correlation of 24-hr urinary protein excretion with both urinary protein/creatinine ratio (Up/Ucr) and Up/Uosm was highly significant (p<0.001). According to the receiver operator characteristic (ROC) curves analysis, we found no differences between Up/Uosm and Up/Ucr ratios in detecting either abnormal proteinuria or nephrotic syndrome.  Conclusion: Urine protein to urine osmolality ratio seems to be a simple and a valuable test for the assessment of the degree of proteinuria in children. UR - https://ijms.sums.ac.ir/article_40159.html L1 - https://ijms.sums.ac.ir/article_40159_59970b65896abe8163806729cc1fa2f1.pdf ER -