Iranian Journal of Medical Sciences

Document Type: Case Report(s)


1 Departments of Pathology, Shiraz University of Medical Sciences, Shiraz

2 Departments of Orthopaedic Surgery, Shiraz University of Medical Sciences, Shiraz


Epitheloid osteosarcoma (carcinosarcoma) of the bone is a rare malignant tumor and only a few cases have been reported in the literature. In this study, we report two cases of osseous carcinosarcoma (epitheloid osteosarcoma) with immunohistochemical studies.  The morphological and immunohistochemical data in these two cases support the theory of divergent differentiation of primitive, uncommitted multipotiential stem cell to produce biphenotypic tumors.