%0 Journal Article %T Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats %J Iranian Journal of Medical Sciences %I Shiraz University of Medical Sciences %Z 0253-0716 %A Shidfar, Farzad %A Faghihi, Amirhosein %A Lorvand Amiri, Hamid %A Mousavi, Seyedeh Neda %D 2018 %\ 01/01/2018 %V 43 %N 1 %P 26-31 %! Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats %K Fatty liver %K Trigelycerids %K Lipid profile %K Selenium %K Zink %K Cholestrol %R 10.30476/ijms.2018.40508 %X Background: Studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (NAFLD). However, the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD are not clear enough. The aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD prognosis.Methods: Forty male Sprague–Dawley rats (197±4 g) were randomly assigned to 4 dietary groups: normal-fat diet (NFD; receiving 9% of calories as fat), high-fat diet (HFD; receiving 82% of calories as fat), supplementation before disease progression (S+HFD), and supplementation after disease progression (HFD+S). The diets were implemented over a 20-week period in all the groups. Biochemical and histologic parameters were compared between the 4 groups, and between-group comparisons were also carried out.Results: There were significant differences in the average food dietary intake (P %U https://ijms.sums.ac.ir/article_40508_3283036811d7fdd92b9c6ebc5b5a2530.pdf