TY - JOUR ID - 47919 TI - Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Bagheri Lankarani, Kamran AU - Honarvar, Behnam AU - Akbari, Mahsa AU - Bozorgnia, Naghmeh AU - Rabiey Faradonbeh, Maryam AU - Bagherpour, Morteza AU - Nikeghbalian, Saman AU - Shamsaeefar, Alireza AU - Malekhosseini, Seyed Ali AD - Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Industrial Engineering, Iran University of Science and Technology, Tehran, Iran AD - Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2022 PY - 2022 VL - 47 IS - 3 SP - 227 EP - 235 KW - Quality of life KW - Liver KW - Transplantation KW - Waiting list DO - 10.30476/ijms.2021.88302.1895 N2 - Background: The health-related quality of life (HRQOL) in the before liver transplantation (LT) stage has not been studied as much as that after the LT stage. We aimed to assess HRQOL and its determinants before the LT stage. Methods: As a cross-sectional study, HRQOL of all adult patients (n=632) referred to the LT center of Shiraz, Iran in 2018-2019 were assessed. Demographic, socioeconomic, medical, and paraclinical data were requested. Physical (PCS) and mental (MCS) aspects of HRQOL were assessed using the SF36 questionnaire. Univariable, multivariable (linear regression), and confirmatory factor analysis were performed utilizing SPSS 20 and Mplus 6.1 software. p Results: The mean age of the patients was 47.6±12.3 years, while 414 (65.6%) were men, and the mean, score of the model for end-stage liver disease (MELD) was 18.36±5.58. The mean score of QOL, PCS, and MCS was 50.01±21.73, 46.23±23.23, and 53.78±23.91 (out of 100), respectively. Vitality had the most association with HRQOL, while role limitations had the lowest. The multivariable analysis revealed that unemployment (p <0.001), anemia (P=0.005), weight loss (P=0.005), diabetes mellitus (DM) (P=0.009), low MELD score (P=0.027), and drug use (P=0.03) were the significant determinants of HRQOL, respectively.Conclusion: The present study showed that HRQOL in the LT candidates was at the intermediate level, while their PCS and MCS are at the low and moderate levels, respectively. Furthermore, physical performance, job status, anemia, weight loss, MELD score, DM, and drug use should be considered as the significant determinants of HRQOL in the LT candidates. UR - https://ijms.sums.ac.ir/article_47919.html L1 - https://ijms.sums.ac.ir/article_47919_1fcd6d3b444cf8089073895d74f61233.pdf ER -