Postpartum Hypercalcemia Secondary to a Neuroendocrine Tumor of Pancreas; a Case Report and Review of Literature

Document Type: Case Report(s)

Authors

1 Research Institute for Endocrine Sci-ences, Taleghani General Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Department of Surgery, Kasra General Hospital, Tehran Iran

3 Department of Internal Medicine, Ta-leghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Department of Radiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Department of Internal Medicine, Hashemi Nejad Hospital, Iran University of Medical Sciences, Tehran, Iran

6 Department of Obstetrics and Gynechology, Kasra General Hospital, Tehran, Iran

7 Department of Pathology, Imam Kho-meini Hospital, Tehran University of Medical Sciences, Tehran, Iran

8 Department of Laboratory Medicine, Saint Michael’s Hospital, University of Toronto, Toronto Ontario, Canada

Abstract

Parathyroid hormone-related protein producing pancreatic neuroendocrine tumors have been infrequently reported. Herein, we report a case of an Iranian woman who had such a tumor during pregnancy, and gave birth to a female neonate with esophago-tracheal fistula and imperforated anus. Hypercalcemia was diagnosed at postpartum because of elevated serum calcium levels in the neonate and neurologic deterioration of the mother. Extensive literature review revealed 42 cases with pancreatic neuroendocrine tumors and hypercalcaemia. The clinical and laboratory findings of such patients are reviewed in this manuscript.