Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Thrombolytic Therapy for Cerebral Vein Thrombosis in Antiphospholipid Syndrome Secondary to Systemic Lupus Erythematosus

Document Type : Case Report(s)

Authors

Hamid Noshad 1
Mehrzad Hajialilo 2
Reza Mohammadian 3
Ali Reza Khabbazi 2
Mohammad Hossein Daghighi 4
Parviz Saleh 5

1 Department of Nephrology, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

2 Department of Rheumatology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Interventional Neurology, Tabriz University of Medical Sciences, Tabriz, Iran

4 Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran

5 Department of Infectious Disease, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract
A 20-year-old woman was admitted to a Gynecology Hospital in her 6th month of pregnancy for high blood pressure and tonic-clonic seizure. Primary diagnosis was eclampsia, and for that reason she underwent cesarean section. She also had headache on frontal and parietal areas without nausea or vomiting. There was not a focal neurological sign. Rheumatology consultation was requested. Systemic lupus erythematosus and secondary antiphospholipid (APS) was confirmed. The patient had headache that continued several days after cesarean section, therefore, brain magnetic resonance imaging (MRI) and magnetic resonance venography (MRV) were performed, and cerebral vein thrombosis was documented. Distal segment of right lateral sinus and sigmoid sinus were not appeared in brain MRV. Abnormal hypersignal intensity of right lateral sinus/coronal T2 was detected. Thrombolytic therapy with 20 mg tissue plasminogen activator on right sigmoid and transverse sinus was performed by an interventional neurologist. After this procedure, the patient#s headache healed and she was discharged in a good condition.

Keywords

Systemic lupus erythematosus
antiphospholipid syndrome
venous thrombosis
tissue plasminogen activator

  • Received 30 November 2013
  • Revised 24 August 2020
  • Accepted 24 December 2018

Home

Guide for Authors

Submit Manuscript

Guide for Reviewers

Forms

News

Contact Us

FAQ

Suggestion and Complain