Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

The Role of Serum Level of Interleukin-6 in Severity of Pulmonary Complications of Sulfur Mustard Injuries

Document Type : Brief Report(s)

Authors

Majid Shohrati 1
Ali Amini-Harandi 1
Bita Najafian 2
Amin Saburi 3
Mostafa Ghanei 1

1 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Department of Pediatrics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Abstract
Diverse studies suggest that interleukin-6 (IL6), as a member of cytokines family, has a major role in inflammatory processes of airways and lungs. In this study, an attempt was made to determine the serum level of IL6 in sulfur mustard (SM) injured patients and its comparison with controls. The measured IL6 mean level in patients with chemical injuries (0.76±0.3 ng/ml) was significantly higher than the control group’s mean level (0.34±0.12 ng/ml). Furthermore, patients with moderate to severe symptoms had a serum level of (0.95±0.92 ng/ml) which was significantly higher than mild (0.47±0.54) and control (0.34±0.12) groups.The outcome of this research program demonstrates that an increase in serum level of IL6 can have a role in pulmonary complications of SM, similar to other well defined pulmonary diseases. However, further studies are required to clarify the role and mechanism of IL6 in such patients. 

Keywords

Bronchiolitis
Mustard gas
Interleukin-6
Cytokines
Iranian Journal of Medical Sciences
Volume 39, Issue 4 - Serial Number 4
20
July 2014
Pages 382-386

  • Received 01 July 2014
  • Revised 23 August 2020
  • Accepted 24 December 2018

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