Iranian Journal of Medical Sciences

Document Type: Original Article(s)



Background: Primary nocturnal enuresis is a common disorder that often leads to considerable distress in affected children and their family. In many countries pharmacologic therapy is preferred to non-pharmacologic behavioral and conditional alarm therapy. Imipramine, oxybutynin, and desmopressin have been used for enuresis with various efficacies. The aim of the present study was to compare the efficacy of imipramine, oxybutynin, and combined imipramine and oxybutynin in enuretic children aged 6-14 years old. Methods: In a randomized controlled study 89 primary enuretic children who were otherwise normal were allocated to three groups: group A (imipramine users, n=29), group B (oxybutynin users, n=26), and group C (combined imipramine and oxybutynin users, n=34). The number of wet nights per week during control period (2 weeks prior treatment), and treatment period (1 month) were compared in each group and inter groups. Also the cure rate in the treatment period and the relapse rate in the follow up period (1 month) were compared between the three groups. Results: The mean ages in groups A, B, and C were 7.9±1.1 years, 8.2±1.6 years, and 8.2±1.4 years respectively. There was no significant difference in the mean ages in the three groups (P=0.53).In each group the mean number of wet nights per week decreased during treatment period compared with pretreatment period. This reduction was statistically significant (p