Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of these mutations in a group of the population of southern Iran. In total, 198 healthy volunteers with the age range of 1-64 years were selected and screened for factor V Leiden and prothrombin mutations using polymerase chain reaction and restriction fragment length polymorphism techniques. The carrier frequencies for factor V Leiden and prothrombin mutation in the studied cohort were 4.1% and 3.07%, respectively.In the studied area, the allele frequency of factor V is higher than the prothrombin G20210A mutation (0.0204 v 0.0153). According to the data and Hardy-Weinberger equation, the total risk of thrombosis caused by homozygosity and heterozygosity of factor V Leiden, prothrombin G20210A mutation and compound heterozygosity of these mutations are about 1 in 500 individuals.
Karimi, M., Panahandeh Shahraki, G. R., Yavarian, M., Afrasiabi, A., Dehbozorgian, J., Bordbar, M. & Mannucci, P. M. (2009). Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran. Iranian Journal of Medical Sciences, 34(2), 137–140.
MLA
Karimi, M., Panahandeh Shahraki, G. R., Yavarian, M., Afrasiabi, A., Dehbozorgian, J., Bordbar, M., & Mannucci, P. M. "Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran", Iranian Journal of Medical Sciences, 34, 2, 2009, 137–140.
HARVARD
Karimi, M., Panahandeh Shahraki, G. R., Yavarian, M., Afrasiabi, A., Dehbozorgian, J., Bordbar, M., & Mannucci, P. M. (2009). 'Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran', Iranian Journal of Medical Sciences, 34(2), pp. 137–140.
CHICAGO
Karimi, M., Panahandeh Shahraki, G. R., Yavarian, M., Afrasiabi, A., Dehbozorgian, J., Bordbar, M. & Mannucci, P. M., "Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran." Iranian Journal of Medical Sciences, 34 2 (2009): 137–140,
VANCOUVER
Karimi M., Panahandeh Shahraki G. R., Yavarian M., Afrasiabi A., Dehbozorgian J., Bordbar M., Mannucci P. M. Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran. Iranian Journal of Medical Sciences. 2009;34(2):137–140.
