Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Hereditary Spherocytosis Unmasked by Human Parvovirus B19 Induced Aplastic Crisis in a Family

Document Type : Case Report(s)

Authors

Samin Alavi 1
Nahid Arabi 1
Mohammad Kaji Yazdi 2
Mohammad Taghi Arzanian 1
Farahnaz Zohrehbandian 3

1 Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iranii

3 Islamic azad university, North branch

Abstract
Human parvovirus (HPV) B19 induced aplastic crisis in a family leading to the diagnosis of hereditary spherocytosis (HS) is a very rare condition being barely reported in the literature. We herein report a 4-year-old girl, her brother, and their mother who all presented with progressive pallor and jaundice after a febrile illness. The HPV B19 was diagnosed using polymerase chain reaction (PCR) and positive serology for specific anti-HPV B19 IgM. They were further diagnosed with having HS. The clinical importance of this report is that in the case of an abrupt onset of unexplained severe anemia and jaundice, one should consider underlying hemolytic anemias mostly hereditary spherocytosis complicated by HPV B19 aplastic crisis. Herein, we report the occurrence of this condition, simultaneously in three members of a family. The distinguished feature of this report is that all affected family members developed some degrees of transient pancytopenia, not only anemia, all simultaneously in the course of their disease.

Keywords

Hereditary spherocytosis
Parvovirus B19
Pancytopenia
Iranian Journal of Medical Sciences
Volume 40, Issue 5 - Serial Number 5
46
September 2015
Pages 461-464

  • Received 23 July 2013
  • Revised 22 August 2020
  • Accepted 24 December 2018

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