Iranian Journal of Medical Sciences

Document Type: Case Report(s)


1 Endocrine and Metabolism Research Center, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Surgery, Shiraz Uni-versity of Medical Sciences, Shiraz, Iran


The first successful treatment of growth hormone (GH) deficient children with GH extracted from human pituitary was introduced during late 1950's.  The subsequent availability and use of recombinant GH (rhGH) for different clinical conditions raised the question of whether this new therapeutic modality increases the risk of certain conditions such as leukemia or malignancy.  Herein, we report on a 22-year-old man who was diagnosed as a case of GH deficiency at the age of 11 years, was treated with rhGH for 6 years and who developed papillary carcinoma of the thyroid gland 6 years after cessation of the treatment.