Background: Mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (IVIg). Anti-IgA antibody has been proposed to be associated with development of such reactions. Objective: To assess the association between anti-IgA levels of different isotypes and adverse reactions induced in immunodeficient patients following infusion of IVIg. Methods: In this study, IgM, IgG and IgE anti-IgA antibodies were measured by an indirect ELISA method in serum samples from 31 patients with a variety of immunodeficiencies receiving IVIg and 24 normal individuals.Results: Anti-IgA antibody of all three isotypes were detectable in all sera. However, when presented as proportion of total IgA (anti –IgA/total IgA)IgG, IgE isotypes are significantly higher in patients with adverse reactions compared to those without reactions or normal subjects.Conclusion: Both IgG and IgE anti-IgA antibodies may contribute to the development and severity of adverse reactions in some patients receiving IVIg.
Roohi, A., Aghamohammadi, A. & Shokri, F. (2001). Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy. Iranian Journal of Medical Sciences, 26(3-4), 90–94.
MLA
Roohi, A., Aghamohammadi, A., & Shokri, F. "Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy", Iranian Journal of Medical Sciences, 26, 3-4, 2001, 90–94.
HARVARD
Roohi, A., Aghamohammadi, A., & Shokri, F. (2001). 'Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy', Iranian Journal of Medical Sciences, 26(3-4), pp. 90–94.
CHICAGO
Roohi, A., Aghamohammadi, A. & Shokri, F., "Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy." Iranian Journal of Medical Sciences, 26 3-4 (2001): 90–94,
VANCOUVER
Roohi A., Aghamohammadi A., Shokri F. Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy. Iranian Journal of Medical Sciences. 2001;26(3-4):90–94.
