A Rare Complication with the Concomitant use of Warfarin and Nonsteroidal Anti-Inflammatory Drugs: Hemoperitoneum and Intramural Small Bowel Hematoma

Document Type : Letter(s) to the Editor

Authors

¹ Intensive Care Unit, Department of Pulmonary Medicine, Gazi University Faculty of Medicine, Ankara, Turkey

² Intensive Care Unit, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara, Turkey

³ Intensive Care Unit, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey

⁴ Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey

van Dijk KN, Plat AW, van Dijk AA, Piersma-Wichers M, de Vries-Bots AM, Slomp J, et al. Potential interaction between acenocoumarol and diclofenac, naproxen and ibuprofen and role of CYP2C9 genotype. Thromb Haemost. 2004;91:95-101. doi: 10.1160/TH03-05-0325. PubMed PMID: 14691574.
Stading JA, Skrabal MZ, Faulkner MA. Seven cases of interaction between warfarin and cyclooxygenase-2 inhibitors. Am J Health Syst Pharm. 2001;58:2076-80. PubMed PMID: 11715832.
Schaefer MG, Plowman BK, Morreale AP, Egan M. Interaction of rofecoxib and celecoxib with warfarin. Am J Health Syst Pharm. 2003;60:1319-23. PubMed PMID: 12901032.
Altikaya N, Parlakgumus A, Demir S, Alkan O, Yildirim T. Small bowel obstruction caused by intramural hematoma secondary to warfarin therapy: a report of two cases. Turk J Gastroenterol. 2011;22:199-202. PubMed PMID: 21796559.
Abdel Samie A, Sun R, Huber A, Hopfner W, Theilmann L. Spontaneous intramural small-bowel hematoma secondary to anticoagulant therapy: a case series. Med Klin Intensivmed Notfmed. 2013;108:144-8. doi: 10.1007/s00063-012-0184-0. PubMed PMID: 23135686.

Iranian Journal of Medical Sciences