Aqueous Extract of Anethum Graveolens L. has Potential Antioxidant and Antiglycation Effects

Abbasi Oshaghi, Ebrahim; Khdadadi, Iraj; Tavilani, Heidar; Goodarzi, Mohammad Taghi

doi:10.30476/ijms.2016.40370

Aqueous Extract of Anethum Graveolens L. has Potential Antioxidant and Antiglycation Effects

Document Type : Brief Report(s)

Authors

Ebrahim Abbasi Oshaghi ¹

Iraj Khdadadi ¹

Heidar Tavilani ¹

Mohammad Taghi Goodarzi ²

¹ Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

² Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; and Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

https://doi.org/10.30476/ijms.2016.40370

Abstract

The aim of this study was to assess the antiglycation and antioxidant properties of aqueous extract of Anethum graveolens (dill). In the in vivo and in vitro experiments, antioxidant properties, blood glucose, and AGEs formation were determined. Dill extract was given orally to healthy and diabetic rats. Our results illustrated that different concentrations of dill extract (0.125, 0.25, 0.5, and 1 mg/ml) have potential antiradical and antioxidant activity. Aqueous extract of dill significantly reduced AGEs formation and fructosamine levels, protein carbonyl and also thiol group’s oxidation, amyloid cross-β and fragmentation. After 2 months, blood glucose levels (P=0.006) and AGEs formation (P=0.003) significantly reduced in dill treated group compared with untreated diabetic animals. In conclusion, dill can be recommended as herbal medicine for the control and prevention of diabetic complications.

Keywords

Anethum graveolens

Antioxidants

Herbal medicine

Hypoglycemic agents

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