Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Renal Medullary Carcinoma; A Rare Entity

Document Type : Case Report(s)

Authors

Selahattin Çalışkan 1
Ali Murat Gökçe 2
Gülistan Gümrükçü 3
Mine Önenerk 3

1 Department of Urology, Çorum Training and Research Hospital, Hitit University, Çorum,Turkey

2 Department of Surgery, Haydarpaşa Numune Training and Research Hospital, İstanbul ,Turkey

3 Department of Pathology,Haydarpaşa Numune Training and Research Hospital, İstanbul,Turkey

Abstract
AbstractRenal medullary carcinoma (RMC) is an uncommon aggressive neoplasm of the kidney. RMC is biologically aggressive with a very poor prognosis, and metastasis is seen in up to 95% of the patients at diagnosis or shortly thereafter. The common sites of metastasis are respectively lymph nodes, lungs, livers, and adrenal glands in order of frequency. The presence of poorly differentiated eosinophilic cells in a characteristic fibro-inflammatory stroma is seen in histological examination. The origin and pathogenesis of RMC are unclear. The radiographical and pathological findings suggest that RMC probably originates in the calyceal epithelium in or near the renal papillae, which could be the result of chronic ischemic damage in the renal papillae epithelium by sickled erythrocytes. Positivity of VEGF and HIF-1α supports the chronic hypoxia that may be caused in the pathogenesis of RMC. Other factors such as genetic or environmental factors are important. Although hemoglobinopathy is very common, RMC is very rare. An understanding of the molecular and genetic factors of this rare disease is important for its prevention and treatment. We herein describe an adult Turkish patient, who presented with hematuria. The diagnosis was RMC after pathological examination.

Keywords

Medullary carcinoma
Kidney neoplasms
Case reports
Iranian Journal of Medical Sciences
Volume 42, Issue 2 - Serial Number 2
84
March 2017
Pages 215-218

  • Received 06 May 2015
  • Revised 17 October 2021
  • Accepted 24 December 2018

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