Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

A Rare Case of Fixed Drug Eruption due to Ondansetron

Document Type : Case Report(s)

Authors

Aditi Maitra 1
Shashwat Bhattacharyya 2
Sabyasachi Paik 1
Prerna Pathak 3
Santanu Kumar Tripathi 1

1 Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India;

2 Department of Ophthalmology, Calcutta National Medical College, Kolkata, India

3 Department of Dermatology and Venereology, Calcutta School of Tropical Medicine, Kolkata, India

Abstract
AbstractFixed drug eruption (FDE) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. FDE is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. A 27-year-old woman presented with multiple dark patches over her eyelids, mouth, lips, and shoulders of 1 week’s duration. These lesions followed multiple erythematous plaques over the same areas which appeared within 4 hours of the intake of an ondansetron tablet, 12 days previously. The case was diagnosed as post-inflammatory hyperpigmentation following ondansetron-induced FDE. There was an identical episode 1 year earlier due to the intake of the same drug. The causality assessment pointed toward a probable/likely association as per the Naranjo algorithm and the WHO–UMC scale. There have been only a few cases of FDE due to ondansetron in the reported literature.

Keywords

Ondansetron
Hyperpigmentation
Fixed drug eruption
5HT3 receptor antagonists
Iranian Journal of Medical Sciences
Volume 42, Issue 5 - Serial Number 5
88
September 2017
Pages 497-500

  • Received 28 February 2016
  • Revised 17 October 2021
  • Accepted 24 December 2018

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