Iranian Journal of Medical Sciences

Document Type: Original Article(s)

Authors

1 Iran National Science Foundation, Tehran, Iran; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; and Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran

2 Iran National Science Foundation, Tehran, Iran; and Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran

3 Iran National Science Foundation, Tehran, Iran; and Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

4 Iran National Science Foundation, Tehran, Iran; and Department of Biochemistry and Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Abstract

Background: Studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (NAFLD). However, the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD are not clear enough. The aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD prognosis.Methods: Forty male Sprague–Dawley rats (197±4 g) were randomly assigned to 4 dietary groups: normal-fat diet (NFD; receiving 9% of calories as fat), high-fat diet (HFD; receiving 82% of calories as fat), supplementation before disease progression (S+HFD), and supplementation after disease progression (HFD+S). The diets were implemented over a 20-week period in all the groups. Biochemical and histologic parameters were compared between the 4 groups, and between-group comparisons were also carried out.Results: There were significant differences in the average food dietary intake (P

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