Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Intralesional Injection of the Measles–Mumps–Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial

Document Type : Original Article(s)

Authors

Mohammad Sadegh Rezai 1
Hiva Ghasempouri 2
Ozra Asqary Marzidareh 2
Jamshid Yazdani Cherati 3
Ghasem Rahmatpour Rokni 4

1 Pediatric Infectious Diseases Superspecialist, Infectious Diseases Research Center with focus on Nosocomial Infections, Mazandaran University of Medical Sciences, Sari, Ira

2 General physician, Mazandaran University of Medical Sciences, Sari, Iran

3 Epidemiologist, Department of Biostatistics, Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran

4 General physician, Mazandaran University of Medical Sciences, Sari, Iran and Dermatologist, Clinical Research Development Unit of Bou-Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran

https://doi.org/10.30476/ijms.2019.40613
Abstract
Background: Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (HPV) infection. The aim of the present study was to evaluate the effects of the intralesional injection of the measles–mumps–rubella (MMR) vaccine into resistant-to- treatment palmoplantar warts and its complications.Methods: In this single-blind, randomized, controlled clinical trial, 60 cases with resistant-to-therapy palmoplantar warts referring to the Dermatology Clinic of Bou-Ali Sina Hospital of Sari between June 2015 and 2016 were randomly assigned to 2 equal groups: the MMR Group received intralesional MMR and the Placebo Group was given saline injection. The injections were administered at 2-week intervals until complete clearance was achieved or for a maximum of 5 injections (

Keywords

Injections
Intralesional
Measles–mumps–rubella vaccine
Warts
Iranian Journal of Medical Sciences
Volume 44, Issue 1 - Serial Number 1
97
January 2019
Pages 10-17


  • Received 15 May 2017
  • Revised 22 July 2019
  • Accepted 22 January 2019

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