Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis

Document Type : Case Report(s)

Authors

Mohamed Rida Tagajdid 1
Taoufik Doblali 1
Hicham Elannaz 1
Salaheddine Hammi 2
Bouchra Belfequih 1
Saâd Mrani 1

1 Laboratory of Virology, Mohamed V Souissi University, Mohamed V Military Teaching Hospital, Rabat, BP, Morocco

2 Department of Internal Medicine, Mohamed V Military Teaching Hospital, Rabat, BP, Morocco

Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveolar lavage. Based on observations on biological data, temporal relationship, and clinical features, it could be inferred that the reactivation of cytomegalovirus with viral replication can predispose a person to TEN-SJS. We discuss here, in the light of the current literature, the probable association between drug-induced SJS-TEN and fulminant reactivation of cytomegalovirus.

Keywords

Stevens-Johnson syndrome
Toxic epidermal necrolysis
Cytomegalovirus
Pneumonia
Iranian Journal of Medical Sciences
Volume 38, June Supplement 2013
June 2013
Pages 195-197

  • Received 30 November 2013
  • Revised 23 August 2020
  • Accepted 06 March 2019

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