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Epidemiology of Hepatitis D Virus and Associated Factors in Patients Referred to Level Three Hepatitis Clinic, Fars Province, Southern Iran

Articles InPress

Document Type : Original Article(s)

Authors

1 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Student Research Committee, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran

3 Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

10.30476/ijms.2024.101949.3469

Abstract

Background: Hepatitis D is caused by the hepatitis D virus (HDV) and affects those who have already been infected with the hepatitis B virus (HBV). The epidemiology of hepatitis D in Fars Province, Iran, is poorly understood. This study aimed to investigate the epidemiology of HDV and its associated factors in patients attending Shahid Motahari Clinic, affiliated with Shiraz University of Medical Sciences (Shiraz, Iran).
Methods: This prospective cohort study was conducted in Shiraz, Iran, from 2001 to 2023. This study screened individuals with low HBV viral load and elevated liver enzymes for HDV. Pearson Chi square, Fisher’s exact, and Mann-Whitney U tests were used to examine the univariate associations between hepatitis D and various risk factors. Risk factors with P<0.2 were analyzed using multiple logistic regression to estimate odds ratios and 95% confidence intervals. P<0.05 was considered statistically significant.
Results: The variables were compared between the HDV+ (29) and HDV- (108). The variables of age (P=0.002) and using hookah (P=0.040) were statistically significant. The other variables examined in this study were not statistically significant. Increasing age (OR=1.06, 95% CI=[1.019, 1.102], P=0.003) was identified as a risk factor, while dental visits (OR=0.290 95% CI=[0.101, 0.836], P=0.022) were assessed as a protective factor.
Conclusion: Age was a significant risk factor for HDV infection, while a history of dental procedures appeared to be a protective factor. To better understand the epidemiology of HDV, further comprehensive research is necessary, focusing on diverse demographic groups in different regions.

Keywords

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Iranian Journal of Medical Sciences

Articles InPress, Corrected Proof
Available Online from 18 January 2025
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History
  • Received: 06 March 2024
  • Revised: 03 June 2024
  • Accepted: 28 June 2024
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