Iranian Journal of Medical Sciences

Document Type : Editorial

Author

1 Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

2 Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

10.30476/ijms.2026.51601

Abstract

Alzheimer’s disease appears to be a neurological condition; however, much of its underlying pathology may originate from distant systems outside the brain.

Keywords

  1. Peng L, Zhang Z, Li Q, Song Z, Yan C, Ling H. Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer’s disease: A comprehensive review. Heliyon. 2024;10:e39217. doi: 10.1016/j.heliyon.2024.e39217. PubMed PMID: 39629139; PubMed Central PMCID: PMC11612466.
    Song D, Li Y, Yang LL, Luo YX, Yao XQ. Bridging systemic metabolic dysfunction and Alzheimer’s disease: the liver interface. Mol Neurodegener. 2025;20:61. doi: 10.1186/s13024-025-00849-6. PubMed PMID: 40437610; PubMed Central PMCID: PMC12121119.
    Kearns R. Gut-Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders. Cell Mol Neurobiol. 2024;44:64. doi: 10.1007/s10571-024-01496-z. PubMed PMID: 39377830; PubMed Central PMCID: PMC11461658.
    Xie J, Van Hoecke L, Vandenbroucke RE. The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology. Front Immunol. 2021;12:796867. doi: 10.3389/fimmu.2021.796867. PubMed PMID: 35069578; PubMed Central PMCID: PMC8770958.
    Sait AM, Day PJR. Interconnections between the Gut Microbiome and Alzheimer’s Disease: Mechanisms and Therapeutic Potential. Int J Mol Sci. 2024;25. doi: 10.3390/ijms25168619. PubMed PMID: 39201303; PubMed Central PMCID: PMC11354889.
    Wu B, Liu Y, Li H, Zhu L, Zeng L, Zhang Z, et al. Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance. Neural Regen Res. 2025;20:695-714. doi: 10.4103/1673-5374.391305. PubMed PMID: 38886936; PubMed Central PMCID: PMC11433892. 
    Rahimpour S, Clary BL, Nasoohi S, Berhanu YS, Brown CM. Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses. Aging Dis. 2024;16:3361-80. doi: 10.14336/ad.2024.1293. PubMed PMID: 39751865; PubMed Central PMCID: PMC12539545. 
    Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther. 2023;8:267. doi: 10.1038/s41392-023-01486-5. PubMed PMID: 37433768; PubMed Central PMCID: PMC10336149. 
    Berriat F, Lobsiger CS, Boillée S. The contribution of the peripheral immune system to neurodegeneration. Nat Neurosci. 2023;26:942-54. doi: 10.1038/s41593-023-01323-6. PubMed PMID: 37231108.
    Mroke P, Goit R, Rizwan M, Tariq S, Rizwan AW, Umer M, et al. Implications of the Gut Microbiome in Alzheimer’s Disease: A Narrative Review. Cureus. 2024;16:e73681. doi: 10.7759/cureus.73681. PubMed PMID: 39677207; PubMed Central PMCID: PMC11646158.