Iranian Journal of Medical Sciences

Iranian Journal of Medical Sciences

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Journal Team

Publication Ethics

Indexing and Abstracting

Related Links

Peer Review Process

Journal Metrics

Effects of Sesame Butter (Ardeh) versus Sesame Oil on Metabolic and Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats

Document Type : Original Article(s)

Authors

1 Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;

3 Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

4 Department of Nutritional Science, Arvand International Division of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Background: Diabetes is one of the most common metabolic disorders and is related to oxidative-stress-induced diseases. Given the role of dietary antioxidants in the control and prevention of diabetes, this study aimed to examine the effects of sesame butter versus sesame oil on the serum levels of glucose, lipid profile, and oxidative stress biomarkers in diabetic rats.Methods: Forty male albino rats of Wistar strain were randomly divided into 4 groups (i.e., nondiabetic control rats, diabetic rats, diabetic rats treated with sesame butter, and diabetic rats treated with sesame oil). Experimental diabetes was induced with an intraperitoneal injection of streptozotocin (55 mg/kg). Sesame butter (1.25 g/kg) and sesame oil (0.5 g/kg) were given by oral gavage to the diabetic rats for 6 weeks. Finally, serum glucose, lipid profile, total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were measured and analyzed statistically.Results: Our data showed that the diabetic groups treated with sesame butter and sesame oil had significantly lower levels of glucose and higher levels of high-density lipoprotein than did the diabetic control group at the end of the study (P<0.05). Sesame butter supplementation also increased TAC and decreased MDA concentrations significantly in the diabetic rats (P<0.05).Conclusion: The antihyperglycemic, antioxidative, and partly lipid-lowering effects of sesame butter make it an excellent candidate for future human studies on diabetes, although further research is needed to determine the exact dose and duration of supplementation.

Keywords

References
  1. Islam MS, Choi H. Green tea, anti-diabetic or diabetogenic: a dose response study. Biofactors. 2007;29:45-53. doi: 10.1002/biof.5520290105. PubMed PMID: 17611293.
  2. Zatalia SR, Sanusi H. The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus. Acta Med Indones. 2013;45:141-7. PubMed PMID: 23770795.
  3. Haidari F, Keshavarz SA, Mohammad Shahi M, Mahboob SA, Rashidi MR. Effects of Parsley (Petroselinum crispum) and its Flavonol Constituents, Kaempferol and Quercetin, on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Liver Xanthine Oxidoreductase Aactivity inOxonate-Induced Hyperuricemic Rats. Iran J Pharm Res. 2011;10:811-9. PubMed PMID: 24250417; PubMed Central PMCID: PMC3813066.
  4. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-6. doi: 10.1038/nature05482. PubMed PMID: 17167471.
  5. Gupta RK, Kesari AN, Murthy PS, Chandra R, Tandon V, Watal G. Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J Ethnopharmacol. 2005;99:75‑81. doi: 10.1016/j.jep.2005.01.048. PubMed PMID: 15848023.
  6. Roghani M, Jalali-Nadoushan MR, Baluchnejadmojarad T, Vaez Mahdavi MR, Naderi G, Roghani Dehkordi F, et al. Endothelium-dependent Effect of Sesame Seed Feeding on Vascular Reactivity of Streptozotocin-diabetic Rats: Underlying Mechanisms. Iran J Pharm Res. 2013;12:377-85. PubMed PMID: 24250645; PubMed Central PMCID: PMC3813278.
  7. Sankar D, Rao MR, Sambandam G, Pugalendi KV. A pilot study of open label sesame oil in hypertensive diabetics. J Med Food. 2006;9:408-12. doi: 10.1089/jmf.2006.9.408. PubMed PMID: 17004907.
  8. Sankar D, Ali A, Sambandam G, Rao R. Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. Clin Nutr. 2011;30:351-8. doi: 10.1016/j.clnu.2010.11.005. PubMed PMID: 21163558.
  9. Khaneshi F, Nasrolahi O, Azizi S, Nejati V. Sesame effects on testicular damage in streptozotocin-induced diabetes rats. Avicenna J Phytomed. 2013;3:347-55. PubMed PMID: 25050292; PubMed Central PMCID: PMC4075729.
  10. Nakano D, Kurumazuka D, Nagai Y, Nishiyama A, Kiso Y, Matsumura Y. Dietary sesamin suppresses aortic NADPH oxidase in DOCA salt hypertensive rats. Clin Exp Pharmacol Physiol. 2008;35:324‑6. doi: 10.1111/j.1440-1681.2007.04817.x. PubMed PMID: 17941888.
  11. Miyawaki T, Aono H, Toyoda-Ono Y, Maeda H, Kiso Y, Moriyama K. Antihypertensive effects of sesamin in humans. J Nutr Sci Vitaminol (Tokyo). 2009;55:87-91. doi: 10.3177/jnsv.55.87. PubMed PMID: 19352068.
  12. Rogi T, Tomimori N, Ono Y, Kiso Y. The mechanism underlying the synergetic hypocholesterolemic effect of sesamin and alpha-tocopherol in rats fed a high-cholesterol diet. J Pharmacol Sci. 2011;115:408-16. PubMed PMID: 21372506.
  13. Sankar D, Sambandam G, Ramakrishna Rao M, Pugalendi KV. Modulation of blood pressure, lipid profiles and redox status in hypertensive patients taking different edible oils. Clin Chim Acta. 2005;355:97-104. doi: 10.1016/j.cccn.2004.12.009. PubMed PMID: 15820483.
  14. Eftekhar Sadat B, Khadem Haghighian M, Alipoor B, Malek Mahdavi A, Asghari Jafarabadi M, Moghaddam A. Effects of sesame seed supplementation on clinical signs and symptoms in patients with knee osteoarthritis. Int J Rheum Dis. 2013;16:578-82. doi: 10.1111/1756-185X.12133. PubMed PMID: 24164846.
  15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502. PubMed PMID: 4337382.
  16. Kasetti RB, Rajasekhssar MD, Kondeti VK, Fatima SS, Kumar EG, Swapna S, et al. Antihyperglycemic and antihyperlipidemic activities of methanol: water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food Chem Toxicol. 2010;48:1078-84. doi: 10.1016/j.fct.2010.01.029. PubMed PMID: 20122979.
  17. Ene A, Nwankwo E, Samdi L. Alloxan-induced diabetes in rats and the effects of black caraway (Carum carvi L.) oil on their body weight. Res J Med Med Sci. 2007;2:48-52.
  18. Haidari F, Omidian K, Rafiei H, Zarei M, Mohamad Shahi M. Green Tea (Camellia sinensis) Supplementation to Diabetic Rats Improves Serum and Hepatic Oxidative Stress Markers. Iran J Pharm Res. 2013;12:109-14. PubMed PMID: 24250578; PubMed Central PMCID: PMC3813194.
  19. Borchani C, Besbes S, Blecker C, Attia H. Chemical characteristics and oxidative stability of sesame seed, sesame paste, and olive oils. J Agric Sci Technol. 2010;12:585-96.
  20. Ramesh B, Saravanan R, Pugalendi KV. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. J Med Food. 2005;8:377-81. doi: 10.1089/jmf.2005.8.377. PubMed PMID: 16176150.
  21. Brehm BJ, Lattin BL, Summer SS, Boback JA, Gilchrist GM, Jandacek RJ, et al. One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes. Diabetes Care. 2009;32:215‑20. doi: 10.2337/dc08-0687. PubMed PMID: 18957534; PubMed Central PMCID: PMC2628682.
  22. Martin de Santa Olalla L, Sanchez Muniz FJ, Vaquero MP. N-3 fatty acids in glucose metabolism and insulin sensitivity. Nutr Hosp. 2009;24:113-27. PubMed PMID: 19593479.
  23. Makni M, Fetoui H, Garoui el M, Gargouri NK, Jaber H, Makni J, et al. Hypolipidemic and hepatoprotective seeds mixture diet rich in omega-3 and omega-6 fatty acids. Food Chem Toxicol. 2010;48:2239-46. doi: 10.1016/j.fct.2010.05.055. PubMed PMID: 20510326.
  24. Lim JS, Adachi Y, Takahashi Y, Ide T. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007;97:85-95. doi: 10.1017/S0007114507252699. PubMed PMID: 17217563.
  25. Ide T, Azechi A, Kitade S, Kunimatsu Y, Suzuki N, Nakajima C. Combined effect of sesamin and alpha-lipoic acid on hepatic fatty acid metabolism in rats. Eur J Nutr. 2013;52:1015-27. doi: 10.1007/s00394-012-0408-3. PubMed PMID: 22752262.
  26. Stone NJ. Successful control of dyslipidemia in patients with metabolic syndrome: focus on lifestyle changes. Clin Cornerstone. 2006;8:S15-20. doi: 10.1016/S1098-3597(06)80004-9. PubMed PMID: 16903165.
  27. Elmehdawi R. Hypolipidemia: a word of caution. Libyan J Med. 2008;3:84-90. doi: 10.4176/071221. doi: 10.4176/071221. PubMed PMID: 21499464; PubMed Central PMCID: PMC3074286.
  28. Juskiewicz J, Zdunczyk Z, Jurgonski A, Brzuzan L, Godycka-Klos I, Zary-Sikorska E. Extract of green tea leaves partially attenuates streptozotocin-induced changes in antioxidant status and gastrointestinal functioning in rats. Nutr Res. 2008;28:343-9. doi: 10.1016/j.nutres.2008.03.004. PubMed PMID: 19083430.
  29. Hsu DZ, Chien SP, Li YH, Chuang YC, Chang YC, Liu MY. Sesame oil attenuates hepatic lipid peroxidation by inhibiting nitric oxide and superoxide anion generation in septic rats. JPEN J Parenter Enteral Nutr. 2008;32:154-9. doi: 10.1177/0148607108314766. PubMed PMID: 18407908.
  30. Wichitsranoi J, Weerapreeyakul N, Boonsiri P, Settasatian C, Settasatian N, Komanasin N, et al. Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans. Nutr J. 2011;10:82. doi: 10.1186/1475-2891-10-82. PubMed PMID: 21827664; PubMed Central PMCID: PMC3173298.
  31. Karatzi K, Stamatelopoulos K, Lykka M, Mantzouratou P, Skalidi S, Manios E, et al. Acute and long-term hemodynamic effects of sesame oil consumption in hypertensive men. J Clin Hypertens (Greenwich). 2012;14:630‑6. doi: 10.1111/j.1751-7176.2012.00649.x. PubMed PMID: 22947362.
  32. Hemalatha S, Raghunath M, Ghafoorunissa. Dietary sesame oils inhibits iron-induced oxidative stress in rats [corrected]. Br J Nutr. 2004;92:581-7. PubMed PMID: 15526409.
  33. Hou RC, Huang HM, Tzen JT, Jeng KC. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. J Neurosci Res. 2003;74:123‑33. doi: 10.1002/jnr.10749. PubMed PMID: 13130514.
Iranian Journal of Medical Sciences
Volume 41, Issue 2 - Serial Number 2
75
March 2016
Pages 102-109
Files
History
  • Received: 28 May 2014
  • Revised: 24 November 2024
  • Accepted: 24 December 2018
Share
How to cite
Statistics