Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

The Preventive Role of Pioglitazone in Glycerol-Induced Acute Kidney Injury in Rats during Two Different Treatment Periods

Document Type : Original Article(s)

Authors

Rama Mousleh 1
Shaza Al Laham 1
Ahmad Al-Manadili 2

1 Departmentof Pharmacology and Toxicology, Faculty of Pharmacy, Damascus University, Damascus, Syria

2 Departmentof Oral Histopathology, Faculty of Dentistry, Damascus University, Damascus, Syria

https://doi.org/10.30476/ijms.2018.40527
Abstract
Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period.Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days). Serum urea and creatinine levels were measured to assess the renal function. Reduced glutathione (GSH) levels and histological alterations were also measured. Statistical analysis was performed using Prism (version 6). The numerical data were evaluated by ANOVA, followed by the Tukey tests. The categorical data were evaluated by the Mann–Whitney test and the Fisher exact tests. P

Keywords

Kidney
Glycerol
Rhabdomyolysis
Acute kidney injury
Pioglitazone
Reduced glutathione
Iranian Journal of Medical Sciences
Volume 43, Issue 2 - Serial Number 2
92
March 2018
Pages 184-194


  • Received 25 November 2016
  • Revised 16 March 2020
  • Accepted 24 December 2018

Home

Guide for Authors

Submit Manuscript

Guide for Reviewers

Forms

News

Contact Us

FAQ

Suggestion and Complain