Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

The Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial

Document Type : Original Article(s)

Authors

Sina Bagheri 1
Shahrbanoo Shahbazi 2
Masih Shafa 3
Afshin Borhani-Haghighi 4
Mahsa Kiani 1
Mohammad Mahdi Sagheb 1

1 Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Cardiac Surgery, Shiraz University of Medical Sciences, Shiraz, Ira

4 Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30476/ijms.2018.40581
Abstract
Background: Remote ischemic preconditioning (RIPC) protects other organs from subsequent lethal ischemic injury, but uncertainty remains. We investigated if RIPC could prevent acute kidney injury (AKI) in patients undergoing coronary artery bypass graft (CABG) surgery.Methods: This parallel-group, double-blind, randomized, controlled trial was done on adults undergoing elective or urgent on-pump CABG surgery from 2013 to 2017 in Shiraz, Iran. Patients were allocated to RIPC or control groups through permuted blocking. The patients in the RIPC group received three cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia. We placed an uninflated cuff on the arm for 30 min in the control group. The study primary endpoint was an incidence of AKI. Secondary endpoints included short-term clinical outcomes. We compared categorical and continuous variables using Pearson χ2 and unpaired t tests, respectively. P

Keywords

schemic preconditioning
Reperfusion injury
Acute kidney injury
Coronary artery bypass
Iranian Journal of Medical Sciences
Volume 43, Issue 6 - Serial Number 6
96
November 2018
Pages 587-595


  • Received 05 January 2018
  • Revised 16 March 2020
  • Accepted 24 December 2018

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