Iranian Journal of Medical Sciences

Document Type : Original Article(s)

Authors

1 Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3 Persian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran

4 Molecular Dermatology Research Center, Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

5 Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

6 Department of Dermatology, School of Medicine, Islamic Azad University, Kazeroon Branch, Iran

7 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

10.30476/ijms.2021.91265.2239

Abstract

Background: Non-melanoma skin cancer (NMSC) is the most common type of cancer in the world. In traditional Persian medicine (TPM), various types of temperament (Mizaj) are considered to diagnose, treat, and prevent a variety of illnesses. The present study aimed to evaluate the temperament of patients with NMSC in comparison with a control group.
Methods: A case-control study was conducted in 2018 at the Dermatology Clinic of Shahid Faghihi Hospital affiliated to Shiraz University of Medical Sciences (Shiraz, Iran). A total of 110 patients, aged ≥20 years with confirmed NMSC (case group), and 181 individuals without NMSC (control group) were enrolled in the study. The temperament of the participants in both groups was evaluated using Mojahedi’s Mizaj questionnaire. The data were analyzed using SPSS software and p Results: The results showed that the odds ratio of developing NMSC was 2.62 (95%CI: 1.42-4.83, P=0.002) times higher in individuals with dry temperament than other types of temperament. Moreover, the odds ratio of patients with a history of chronic skin ulcers and other types of cancer was 35.7 (95%CI: 11.9-107.15, p <0.001) and 5.22 (95%CI: 1.43-19.06, P=0.012) times higher, respectively, than the control group.
Conclusion: Temperament is associated with NMSC, particularly the dry temperament type, and should be considered a risk factor.

Keywords

  1. Didona D, Paolino G, Bottoni U, Cantisani C. Non Melanoma Skin Cancer Pathogenesis Overview. Biomedicines. 2018;6. doi: 10.3390/biomedicines6010006. PubMed PMID: 29301290; PubMed Central PMCID: PMCPMC5874663.
  2. Baldi A, Pasquali P, Spugnini EP. Skin cancer: a practical approach. Berlin: Springer Science and Business Media; 2013. doi: 10.1007/978-1-4614-7357-2.
  3. Renier C, Pao E, Che J, Liu HE, Lemaire CA, Matsumoto M, et al. Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology. NPJ Precis Oncol. 2017;1:15. doi: 10.1038/s41698-017-0015-0. PubMed PMID: 29872702; PubMed Central PMCID: PMCPMC5859469
  4. Smith RD. Avicenna and the Canon of Medicine: a millennial tribute. West J Med. 1980;133:367-70. PubMed PMID: 7051568; PubMed Central PMCID: PMCPMC1272342.
  5. Nimrouzi M, Daneshfard B, Parvizi MM. Dream in Persian medicine perspective: a narrative review. International Journal of Dream Research. 2020;13:119-22.
  6. Dousti M, Ramchandani MH, Barkhordarian A, Danaei S, Chiappelli F. Evidence-based traditional persian medicine. Evidence-Based practice in complementary and alternative medicine. Berlin: Springer; 2012. p. 79-96. doi: 10.1007/978-3-642-24565-7_5.
  7. Parvinroo S, Zahediasl S, Sabetkasaei M, Kamalinejad M, Naghibi F. The effects of selected hot and cold temperament herbs based on Iranian traditional medicine on some metabolic parameters in normal rats. Iran J Pharm Res. 2014;13:177-84. PubMed PMID: 24711844; PubMed Central PMCID: PMCPMC3977068.
  8. Parvizi MM, Nimrouzi M, Pasalar M, Salehi A, Hajimonfarednejad M, Amini F, et al. Association between personality types and temperament (Mizaj) based on persian medicine. Shiraz E-Medical Journal. 2018;19:e68950. doi: 10.5812/semj.68950.
  9. Sina I. Al-qanun fi al-tibb [the canon of medicine]. Beirut: Alaalami Library. 2005.
  10. Shah Arzani M. Mofarrah al gholoob (explanation of Ghanoncheh). Edited by Choghamini M Lahore: Islamic Publication. 2010;1:92.
  11. Ahmed NZ, Ansari AP, Anwar N, Shahid M. Cancer perception in Unani medicine–Conceptual analysis. Spatula DD. 2016;6:113-20. doi: 10.5455/spatula.20160613104257.
  12. Iranzadasl M, Mansouri P, Kamalinejad M, Gorji N. Review of skin cancers terminology, etiology and treatment from ancient persian medicine view point. Journal of Medicinal Plants. 2020;19:27-36. doi: 10.29252/jmp.1.73.27.
  13. Shamsi Y, Khan AA, Alam T, Jabeen A. Management of cancer with munzij and mus’hil therapy: a regimen of ilaj bit tadbeer (regimenal therapy) in unani system of medicine. International Journal of Current Research and Review. 2016;8:4.
  14. Mojahedi M, Naseri M, Majdzadeh R, Keshavarz M, Ebadini M, Nazem E, et al. Reliability and Validity Assessment of Mizaj Questionnaire: A Novel Self-report Scale in Iranian Traditional Medicine. Iran Red Crescent Med J. 2014;16:e15924. doi: 10.5812/ircmj.15924. PubMed PMID: 24829785; PubMed Central PMCID: PMCPMC4005447.
  15. Natsuga K, Akiyama M, Shimizu H. Malignant skin tumours in patients with inherited ichthyosis. Br J Dermatol. 2011;165:263-8. doi: 10.1111/j.1365-2133.2011.10381.x. PubMed PMID: 21517795.
  16. Shirbeigi L, Zarei A, Naghizadeh A, Vaghasloo MA. The concept of temperaments in traditional Persian medicine. Traditional and Integrative Medicine. 2017:143-56.
  17. Parvizi MM, Nimrouzi M, Lankarani KB, Morteza S, Alorizi E, Hajimonfarednejad M. Health recommendations for the elderly in the viewpoint of traditional Persian medicine. Shiraz E-Medical Journal. 2018;19:e14201. doi: 10.5812/semj.14201.
  18. Jorjani L. Zakhireh kharazmshahi. Tehran: Bonyade Farhang Iran. 1992. p. 101-74.
  19. Arzani M. Teb-e-Akbari [Akbari’s medicine]. Tehran: Research Institute for Islamic and Complimentary Medicine; 2008.
  20. Ahmad A, Begum M. Sartan (Cancer): Concept and Management in the Literature of Unani Medicine: A Review. Advances in Cancer Research and Therapy. 2015;1:1-5.
  21. Bazalinski D, Przybek-Mita J, Baranska B, Wiech P. Marjolin’s ulcer in chronic wounds - review of available literature. Contemp Oncol (Pozn). 2017;21:197-202. doi: 10.5114/wo.2017.70109. PubMed PMID: 29180925; PubMed Central PMCID: PMCPMC5701580.
  22. Wysong A, Ally MS, Gamba CS, Desai M, Swetter SM, Seiffert-Sinha K, et al. Non-melanoma skin cancer and NSAID use in women with a history of skin cancer in the Women’s Health Initiative. Prev Med. 2014;69:8-12. doi: 10.1016/j.ypmed.2014.08.024. PubMed PMID: 25150382.
  23. Parvizi MM, Zare F, Handjani F, Nimrouzi M, Zarshenas MM. Overview of herbal and traditional remedies in the treatment of cutaneous leishmaniasis based on Traditional Persian Medicine. Dermatol Ther. 2020;33:e13566. doi: 10.1111/dth.13566. PubMed PMID: 32401415.
  24. Zare F, Parvizi MM, Saki N, Jaladat AM. Applications of Ma’aljobon, a natural remedy from traditional Persian medicine, in dermatology: A journey from past to modernity. Dermatol Ther. 2020;33:e13931. doi: 10.1111/dth.13931. PubMed PMID: 32662602.
  25. Jahan N. Eksir-e-Azam. Tehran: Institute for Islamic and Complementary Medicine; 2009.
  26. Rollison DE, Iannacone MR, Messina JL, Glass LF, Giuliano AR, Roetzheim RG, et al. Case-control study of smoking and non-melanoma skin cancer. Cancer Causes Control. 2012;23:245-54. doi: 10.1007/s10552-011-9872-y. PubMed PMID: 22101452.
  27. Leonardi-Bee J, Ellison T, Bath-Hextall F. Smoking and the risk of nonmelanoma skin cancer: systematic review and meta-analysis. Arch Dermatol. 2012;148:939-46. doi: 10.1001/archdermatol.2012.1374. PubMed PMID: 22711192.
  28. Ilkhani R, Aghanouri Z, Mojahedi M, Montazeri A, Siavash M, Tabatabaei F. Comparing Mizaj (temperament) in type 1 diabetes mellitus and healthy controls: A case-control study. J Res Med Sci. 2019;24:58. doi: 10.4103/jrms.JRMS_980_18. PubMed PMID: 31523244; PubMed Central PMCID: PMCPMC6670284.
  29. Salmannezhad H, Mojahedi M, Ebadi A, Montazeri A, Mozaffarpur SA, Saghebi R, et al. An assessment of the correlation between happiness and Mizaj (temperament) of university students in Persian medicine. Iranian Red Crescent Medical Journal. 2017;19:6. doi: 10.5812/ircmj.55627.
  30. Pourshahidi S, Mansourian A, Habibzadeh M, Parvizi MM, Nimrouzi M. Association between geographic tongue and personal temperament based on the knowledge of Persian medicine. Shiraz E-Medical Journal. 2021;22. doi: 10.5812/semj.102456.