Iranian Journal of Medical Sciences

Document Type : Original Article(s)


1 Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3 Persian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran

4 Molecular Dermatology Research Center, Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

5 Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

6 Department of Dermatology, School of Medicine, Islamic Azad University, Kazeroon Branch, Iran

7 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran



Background: Non-melanoma skin cancer (NMSC) is the most common type of cancer in the world. In traditional Persian medicine (TPM), various types of temperament (Mizaj) are considered to diagnose, treat, and prevent a variety of illnesses. The present study aimed to evaluate the temperament of patients with NMSC in comparison with a control group.
Methods: A case-control study was conducted in 2018 at the Dermatology Clinic of Shahid Faghihi Hospital affiliated to Shiraz University of Medical Sciences (Shiraz, Iran). A total of 110 patients, aged ≥20 years with confirmed NMSC (case group), and 181 individuals without NMSC (control group) were enrolled in the study. The temperament of the participants in both groups was evaluated using Mojahedi’s Mizaj questionnaire. The data were analyzed using SPSS software and p Results: The results showed that the odds ratio of developing NMSC was 2.62 (95%CI: 1.42-4.83, P=0.002) times higher in individuals with dry temperament than other types of temperament. Moreover, the odds ratio of patients with a history of chronic skin ulcers and other types of cancer was 35.7 (95%CI: 11.9-107.15, p <0.001) and 5.22 (95%CI: 1.43-19.06, P=0.012) times higher, respectively, than the control group.
Conclusion: Temperament is associated with NMSC, particularly the dry temperament type, and should be considered a risk factor.


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